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SRC-3 a histone acetyltransferase and nuclear receptor coactivator. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Activity is enhanced by various hormones and TNF. Acetylation by CREBBP may suppress coactivation of target genes by disrupting its association with nuclear receptors. Frequently amplified or overexpressed in breast and ovarian cancers. Five alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 20q13.12
Cellular Component: cytoplasm; cytosol; nuclear chromatin; nucleoplasm; nucleus; protein complex
Molecular Function: histone acetyltransferase activity; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; protein binding; protein heterodimerization activity; protein N-terminus binding; transcription coactivator activity
Biological Process: cellular response to hormone stimulus; intracellular receptor-mediated signaling pathway; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter
Reference #:  Q9Y6Q9 (UniProtKB)
Alt. Names/Synonyms: ACTR; AIB-1; AIB1; Amplified in breast cancer 1 protein; BHLHE42; CAGH16; CBP-interacting protein; Class E basic helix-loop-helix protein 42; CTG26; KAT13B; MGC141848; NCoA-3; NCOA3; Nuclear receptor coactivator 3; pCIP; RAC-3; RAC3; Receptor-associated coactivator 3; SRC-3; SRC3; Steroid receptor coactivator protein 3; Thyroid hormone receptor activator molecule 1; TNRC14; TNRC16; TRAM-1; TRAM1
Gene Symbols: NCOA3
Molecular weight: 155,293 Da
Basal Isoelectric point: 7.16  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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