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TACC3 Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May be involved in the control of cell growth and differentiation. May contribute to cancer. Interacts with microtubules. Interacts with CCDC100/CEP120. The coiled coil C-terminus region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2. Interacts with GCN5L2 and PCAF. Up-regulated in various cancer cell lines. Belongs to the TACC family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: cytoplasm; microtubule cytoskeleton
Molecular Function: protein binding
Biological Process: cell proliferation; cerebral cortex development; mitotic metaphase/anaphase transition
Disease: Bladder Cancer
Reference #:  Q9Y6A5 (UniProtKB)
Alt. Names/Synonyms: ERIC-1; ERIC1; MGC117382; MGC133242; TACC3; Transforming acidic coiled-coil-containing protein 3; transforming, acidic coiled-coil containing protein 3
Gene Symbols: TACC3
Molecular weight: 90,360 Da
Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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