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SMRT Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Interacts with BCL6, HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3. Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts (isoform SRMT) with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with CBFA2T3 and ATXN1L. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity. Regulated during cell cycle progression. Ubiquitous. High levels of expression are detected in lung, spleen and brain. Belongs to the N-CoR nuclear receptor corepressors family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: histone deacetylase complex; membrane; nuclear body; nuclear chromatin; nuclear matrix; nucleoplasm; nucleus; transcriptional repressor complex
Molecular Function: histone deacetylase binding; ligand-dependent nuclear receptor binding; Notch binding; protein binding; protein N-terminus binding; transcription corepressor activity; transcription factor binding
Biological Process: negative regulation of transcription from RNA polymerase II promoter; regulation of lipid metabolic process
Reference #:  Q9Y618 (UniProtKB)
Alt. Names/Synonyms: CTG repeat protein 26; CTG26; FLJ25011; N-CoR2; NCOR2; nuclear receptor co-repressor 2; Nuclear receptor corepressor 2; silencing mediator for retinoid and thyroid hormone receptors; Silencing mediator of retinoic acid and thyroid hormone receptor; SMAP270; SMRT; SMRTE; SMRTE-tau; T3 receptor-associating factor; Thyroid-, retinoic-acid-receptor-associated corepressor; TNRC14; TRAC; TRAC-1; TRAC1
Gene Symbols: NCOR2
Molecular weight: 274,804 Da
Basal Isoelectric point: 7.21  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling  |  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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