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IRS2 May mediate the control of various cellular processes by insulin. Interacts with PHIP. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: cytosol; plasma membrane
Molecular Function: 1-phosphatidylinositol-3-kinase activity; insulin receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphoinositide 3-kinase binding; protein binding; Ras guanyl-nucleotide exchange factor activity; signal transducer activity
Biological Process: axon guidance; cellular response to insulin stimulus; glucose metabolic process; insulin receptor signaling pathway; lipid homeostasis; MAPKKK cascade; negative regulation of B cell apoptosis; negative regulation of kinase activity; phosphoinositide-mediated signaling; positive regulation of B cell proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of insulin secretion; regulation of lipid metabolic process; regulation of phosphoinositide 3-kinase cascade; response to glucose stimulus; signal transduction
Disease: Diabetes Mellitus, Noninsulin-dependent
Reference #:  Q9Y4H2 (UniProtKB)
Alt. Names/Synonyms: Insulin receptor substrate 2; IRS-2; IRS2
Gene Symbols: IRS2
Molecular weight: 137,334 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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