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SMC3 Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement. Interacts with MXI1, MXD3 and MXD4. Interacts with SYCP2. Found in a complex with SMC1A, CDCA5 and RAD21, PDS5A/APRIN and PDS5B/SCC-112. Forms a heterodimer with SMC1A or SMC1B in cohesin complexes. Cohesin complexes are composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. Also found in meiosis-specific cohesin complexes. Interacts with NUMA1, and forms a ternary complex with KIF3B and KIFAP3, suggesting a function in tethering the chromosomes to the spindle pole and in chromosome movement. Interacts with PDS5A and WAPAL; regulated by SMC3 acetylation. Belongs to the SMC family. SMC3 subfamily. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; DNA repair, damage
Chromosomal Location of Human Ortholog: 10q25.2
Cellular Component: basement membrane; chromatin; chromosome; chromosome, pericentric region; cytoplasm; cytosol; intracellular; nuclear matrix; nucleoplasm; nucleus; spindle pole
Molecular Function: protein binding; protein heterodimerization activity
Biological Process: interaction with symbiont; meiotic cell cycle; mitotic cell cycle; negative regulation of DNA endoreduplication; regulation of DNA replication; sister chromatid cohesion
Disease: Cornelia De Lange Syndrome 3
Reference #:  Q9UQE7 (UniProtKB)
Alt. Names/Synonyms: BAM; Bamacan; Basement membrane-associated chondroitin proteoglycan; BMH; CDLS3; Chondroitin sulfate proteoglycan 6; chondroitin sulfate proteoglycan 6 (bamacan); Chromosome-associated polypeptide; CSPG6; hCAP; SMC protein 3; SMC-3; SMC3; SMC3L1; structural maintenance of chromosomes 3; Structural maintenance of chromosomes protein 3
Gene Symbols: SMC3
Molecular weight: 141,542 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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