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Protein Page:
Fyn

Overview
Fyn a tyrosine kinase of the Src family. Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC. Associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Three alternatively spliced isoforms have been described. Isoform 2 shows a greater ability to mobilize cytoplasmic calcium than isoform 1. Induced expression aids in cellular transformation and xenograft metastasis. In squamous cell carcinoma, Fyn transduces signals from EGFR and Src and is required for cell migration and invasiveness. Activity linked to migration in a murine melanoma model. Appears to block late stage development of neuroblastoma. Mouse knockout deficient in kindling response, a model for human epilepsy. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: actin filament; cytosol; dendrite; endosome; extrinsic component of cytoplasmic side of plasma membrane; membrane raft; mitochondrion; nucleus; plasma membrane; postsynaptic density
Molecular Function: ATP binding; CD4 receptor binding; CD8 receptor binding; ephrin receptor binding; identical protein binding; ion channel binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; peptide hormone receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphoinositide 3-kinase binding; protein binding; protein tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; signal transducer activity; T cell receptor binding; tau protein binding; tubulin binding; type 5 metabotropic glutamate receptor binding
Biological Process: activated T cell proliferation; adaptive immune response; axon guidance; blood coagulation; calcium ion transport; cell differentiation; cell migration; cellular response to peptide hormone stimulus; cellular response to transforming growth factor beta stimulus; central nervous system development; dendrite morphogenesis; detection of mechanical stimulus involved in sensory perception of pain; ephrin receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; feeding behavior; forebrain development; innate immune response; interleukin-7-mediated signaling pathway; learning; leukocyte migration; MAPK cascade; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of gene expression; negative regulation of neuron apoptosis; negative regulation of protein catabolic process; negative regulation of protein ubiquitination; neuron migration; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphatidylinositol phosphorylation; platelet activation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of neuron death; positive regulation of neuron projection development; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling; positive regulation of protein localization to nucleus; positive regulation of protein targeting to membrane; positive regulation of tyrosine phosphorylation of STAT protein; protein amino acid phosphorylation; regulation of apoptosis; regulation of calcium ion import across plasma membrane; regulation of cell proliferation; regulation of cell shape; regulation of defense response to virus by virus; regulation of molecular function; regulation of peptidyl-tyrosine phosphorylation; response to amyloid-beta; response to drug; response to ethanol; stimulatory C-type lectin receptor signaling pathway; T cell activation; T cell costimulation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway
Reference #:  P06241 (UniProtKB)
Alt. Names/Synonyms: c-syn protooncogene; FYN; FYN oncogene related to SRC, FGR, YES; MGC45350; OKT3-induced calcium influx regulator; p59-Fyn; protein-tyrosine kinase fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; proto-oncogene tyrosine-protein kinase fyn; SLK; src-like kinase; src/yes-related novel; SYN; tyrosine kinase p59fyn(T); Tyrosine-protein kinase Fyn
Gene Symbols: FYN
Molecular weight: 60,762 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Fyn

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