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Protein Page:

TPX2 a microtubule-associated protein required for meiotic and mitotic spindle assembly. Targets a plus end-directed motor (XKLP2) to the minus ends of microtubules in the mitotic spindle. Required for microtubule nucleation around chromosomes in response to the local generation of RanGTP. Binds to and activates Aurora A kinase and targets it to the mitotic spindle. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Microtubule-binding
Chromosomal Location of Human Ortholog: 20q11.21
Cellular Component: cytosol; microtubule cytoskeleton; nucleoplasm; nucleus; spindle; spindle pole
Molecular Function: ATP binding; GTP binding; protein binding; protein kinase binding
Biological Process: activation of protein kinase activity; cell proliferation; G2/M transition of mitotic cell cycle; mitotic cell cycle
Reference #:  Q9ULW0 (UniProtKB)
Alt. Names/Synonyms: C20orf1; C20orf2; Differentially expressed in cancerous and non-cancerous lung cells 2; differentially expressed in lung cells; DIL-2; DIL2; FLS353; GD:C20orf1; HCA519; HCTP4; Hepatocellular carcinoma-associated antigen 519; p100; preferentially expressed in colorectal cancer; Protein fls353; REPP86; restricted expression proliferation associated protein 100; Restricted expression proliferation-associated protein 100; Targeting protein for Xklp2; TPX2; TPX2, microtubule-associated protein homolog; TPX2, microtubule-associated, homolog (Xenopus laevis)
Gene Symbols: TPX2
Molecular weight: 85,653 Da
Basal Isoelectric point: 9.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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