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FLT3 a receptor tyrosine kinase of the PDGFR family that binds the FL cytokine. FLT3 -/- mice have an impaired developmental capacity of primitive hematopoietic progenitor cells of all lineages with the greatest impact on lymphopoietic precursors. Activating mutations found in one third of cases of acute myeloid leukemia (AML), as well as in acute lymphoblastic leukemia, acute promyelocytic leukemia and myelodysplastic syndrome. Inhibitors: Sutent and PKC412. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Oncoprotein; PDGFR family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 13q12.2
Cellular Component: cytosol; endoplasmic reticulum; endoplasmic reticulum lumen; integral component of plasma membrane; nucleus; plasma membrane; protein complex
Molecular Function: ATP binding; glucocorticoid receptor binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protein complex binding; protein homodimerization activity; protein self-association; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor-activated receptor activity
Biological Process: B cell differentiation; cellular response to cytokine stimulus; cellular response to glucocorticoid stimulus; cytokine-mediated signaling pathway; hemopoiesis; leukocyte homeostasis; lymphocyte proliferation; myeloid progenitor cell differentiation; organ regeneration; peptidyl-tyrosine phosphorylation; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of tyrosine phosphorylation of STAT protein; pro-B cell differentiation; protein autophosphorylation; regulation of apoptosis; response to organonitrogen compound; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor signaling pathway
Disease: Leukemia, Acute Lymphoblastic
Reference #:  P36888 (UniProtKB)
Alt. Names/Synonyms: CD135; CD135 antigen; fetal liver kinase 2; FL cytokine receptor; FLK2; FLT-3; FLT3; FLT3 receptor tyrosine kinase; Fms-like tyrosine kinase 3; fms-related tyrosine kinase 3; growth factor receptor tyrosine kinase type III; Stem cell tyrosine kinase 1; STK-1; STK1; Tyrosine-protein kinase receptor FLT3
Gene Symbols: FLT3
Molecular weight: 112,903 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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