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Protein Page:

HDAC6 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD. Interacts with ZMYND15. Belongs to the histone deacetylase family. HD type 2 subfamily. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; EC; Nuclear receptor co-regulator; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: axon; caveola; cytoplasm; cytosol; dendrite; dynein complex; histone deacetylase complex; inclusion body; leading edge; microtubule; microtubule associated complex; multivesicular body; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm
Molecular Function: alpha-tubulin binding; beta-catenin binding; enzyme binding; histone deacetylase activity; histone deacetylase binding; Hsp90 protein binding; microtubule binding; misfolded protein binding; polyubiquitin binding; protein binding; tau protein binding; tubulin deacetylase activity; ubiquitin protein ligase binding
Biological Process: histone deacetylation; intracellular protein transport; lysosome localization; misfolded or incompletely synthesized protein catabolic process; negative regulation of oxidoreductase activity; negative regulation of protein complex disassembly; negative regulation of proteolysis; negative regulation of transcription, DNA-dependent; positive regulation of signal transduction; protein amino acid deacetylation; regulation of autophagy; regulation of gene expression, epigenetic; regulation of macroautophagy; regulation of protein stability; regulation of receptor activity; response to misfolded protein; response to organic substance; response to toxin
Disease: Chondrodysplasia With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia
Reference #:  Q9UBN7 (UniProtKB)
Alt. Names/Synonyms: FLJ16239; HD6; HDAC6; Histone deacetylase 6; JM21; KIAA0901
Gene Symbols: HDAC6
Molecular weight: 131,419 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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