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SIN3A Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Interacts with BAZ2A, MXD3, MXD4, MBD2, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1 and SMYD2. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with ARID4B, BRMS1L, DACH1, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ, SUDS3 and TOPORS. Interacts with TET1; the interaction recruits SIN3A to gene promoters. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 15q24.2
Cellular Component: nucleoplasm; nucleus; Sin3 complex
Molecular Function: histone deacetylase activity; protein binding; protein deacetylase activity
Biological Process: activation of innate immune response; histone deacetylation; negative regulation of circadian rhythm; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of chromatin silencing; positive regulation of defense response to virus by host; positive regulation of transcription from RNA polymerase II promoter; protein amino acid deacetylation; regulation of lipid metabolic process
Disease: Witteveen-kolk Syndrome
Reference #:  Q96ST3 (UniProtKB)
Alt. Names/Synonyms: DKFZp434K2235; FLJ90319; Histone deacetylase complex subunit Sin3a; KIAA0700; Paired amphipathic helix protein Sin3a; SIN3 homolog A, transcription regulator (yeast); SIN3A; transcriptional co-repressor Sin3A; Transcriptional corepressor Sin3a; transcriptional regulator, SIN3A
Gene Symbols: SIN3A
Molecular weight: 145,175 Da
Basal Isoelectric point: 6.82  Predict pI for various phosphorylation states
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