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Symplekin Heat-labile component of a multimolecular complex that function in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. May be required for pre-mRNA polyadenylation. Found in a heat-sensitive complex at least composed of several cleavage and polyadenylation specific and cleavage stimulation factors. Interacts with CPSF2, CPSF3 and CSTF2. Interacts with HSF1 in heat-stressed cells. In testis, expressed in polar epithelia and Sertoli cells but not in vascular endothelia. The protein is detected in stomach, duodenum, pancreas, liver, fetal brain, carcinomas, lens-forming cells, fibroblasts, lymphocytes, lymphoma cells, erythroleukemia cells but not in endothelium of vessels, epidermis, intercalated disks, Purkinje fiber cells of the heart and lymph node. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; RNA processing
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component: cytoplasm; cytosol; nucleoplasm; plasma membrane
Molecular Function: protein binding
Biological Process: mRNA 3'-end processing; mRNA export from nucleus; mRNA polyadenylation; nuclear mRNA splicing, via spliceosome; positive regulation of protein amino acid dephosphorylation; termination of RNA polymerase II transcription
Reference #:  Q92797 (UniProtKB)
Alt. Names/Synonyms: FLJ27092; SPK; SYM; SYMPK; Symplekin
Gene Symbols: SYMPK
Molecular weight: 141,148 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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