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AKAP1 Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. AKAP149 is highly expressed in prostate and small intestine whereas S-AKAP84 is expressed in kidney, pancreas, liver, lung and brain. AKAP149 is also expressed in colon carcinoma. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral; Mitochondrial; RNA-binding
Chromosomal Location of Human Ortholog: 17q22
Cellular Component: cytosol; membrane; mitochondrion
Molecular Function: protein binding; RNA binding
Biological Process: blood coagulation
Reference #:  Q92667 (UniProtKB)
Alt. Names/Synonyms: A kinase (PRKA) anchor protein 1; A kinase anchor protein 1, mitochondrial; A-kinase anchor protein 149 kDa; A-kinase anchor protein, 149kD; AKAP; AKAP 149; AKAP1; AKAP121; AKAP149; AKAP84; D-AKAP-1; D-AKAP1; Dual specificity A-kinase-anchoring protein 1; dual-specificity A-kinase anchoring protein 1; MGC1807; PRKA1; protein kinase A anchoring protein 1; Protein kinase A-anchoring protein 1; protein kinase A1; S-AKAP84; SAKAP84; Spermatid A-kinase anchor protein 84
Gene Symbols: AKAP1
Molecular weight: 97,342 Da
Basal Isoelectric point: 4.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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