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NDRG1 a hypoxia-inducible anti-apoptotic protein. Promotes proliferation and correlates with invasion, metastasis and poor prognosis in many cancers. Is involved in growth arrest and cell differentiation during development. A ubiquitous Rab4a effector protein that modulates angiogenesis and is involved in vesicular recycling of E-cadherin. Colocalizes with transferrin during the recycling in cells. NDRG1 knockdown delays the recycling rate of transferrin, while its overexpression increases the rate of transferrin recycling. Interacts with SIRT1/p53 signaling to attenuate hypoxic injury in human trophoblasts. Its expression is induced by an elevation of free intracellular calcium ion caused by nickel ion exposure. Highly expressed in placental membranes, prostate, kidney, small intestine, ovary, peripheral nerves and Schwann cells. Defects in NDRG1 are the cause of Charcot-Marie-Tooth disease type 4D (CMT4D). Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Vesicle
Chromosomal Location of Human Ortholog: 8q24.22
Cellular Component: cell-cell adherens junction; centrosome; cytoplasm; cytosol; microtubule; microtubule cytoskeleton; nucleus; perinuclear region of cytoplasm; plasma membrane; recycling endosome membrane
Molecular Function: cadherin binding; gamma-tubulin binding; microtubule binding; protein binding; Rab GTPase binding
Biological Process: DNA damage response, signal transduction by p53 class mediator; regulation of apoptosis; response to metal ion
Disease: Charcot-marie-tooth Disease, Type 4d
Reference #:  Q92597 (UniProtKB)
Alt. Names/Synonyms: CAP43; CMT4D; Differentiation-related gene 1 protein; DRG-1; DRG1; GC4; HMSNL; N-myc downstream regulated 1; N-myc downstream-regulated gene 1 protein; NDR1; NDRG1; Nickel-specific induction protein Cap43; NMSL; Protein NDRG1; protein regulated by oxygen-1; PROXY1; Reducing agents and tunicamycin-responsive protein; Rit42; RTP; TARG1; TDD5; tunicamycin-responsive protein
Gene Symbols: NDRG1
Molecular weight: 42,835 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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