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Protein Page:

Pumilio-2 Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; RNA-binding; Translation
Chromosomal Location of Human Ortholog: 2p24.1
Cellular Component: cytosol; nuclear membrane; perinuclear region of cytoplasm; stress granule
Molecular Function: mRNA 3'-UTR binding; protein binding; RNA binding
Biological Process: regulation of chromosome segregation; regulation of mRNA stability
Reference #:  Q8TB72 (UniProtKB)
Alt. Names/Synonyms: FLJ36528; KIAA0235; MGC138251; MGC138253; PUM2; PUMH2; Pumilio homolog 2; pumilio homolog 2 (Drosophila); Pumilio-2; PUML2
Gene Symbols: PUM2
Molecular weight: 114,216 Da
Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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