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STAG2 Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 is mutually exclusive with STAG1 and STAG3. Belongs to the SCC3 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: Xq25
Cellular Component: chromatin; chromosome; chromosome, pericentric region; cytosol; membrane; nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: negative regulation of DNA endoreduplication; sister chromatid cohesion
Reference #:  Q8N3U4 (UniProtKB)
Alt. Names/Synonyms: bA517O1.1; Cohesin subunit SA-2; DKFZp686P168; DKFZp781H1753; FLJ25871; SA-2; SA2; SCC3 homolog 2; STAG2; Stromal antigen 2
Gene Symbols: STAG2
Molecular weight: 141,326 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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