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Zyxin Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression. Interacts with HPV type 6 protein E6. Does not interact significantly with E6 proteins from HPV types 11, 16, or 18. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES. Interacts with NEBL (isoform 2). Belongs to the zyxin/ajuba family. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q34
Cellular Component: cell-cell adherens junction; cytosol; focal adhesion; integral to plasma membrane; nucleus; plasma membrane; stress fiber
Molecular Function: protein binding; RNA binding
Biological Process: cell adhesion; cell-cell signaling; cell-matrix adhesion; integrin-mediated signaling pathway; signal transduction; stress fiber formation; transforming growth factor beta receptor signaling pathway
Reference #:  Q15942 (UniProtKB)
Alt. Names/Synonyms: ESP-2; HED-2; ZYX; Zyxin; Zyxin-2
Gene Symbols: ZYX
Molecular weight: 61,277 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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