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DAPK1 a CAMK protein kinase of the Death-associated protein kinase (DAPK) family. Mediates autophagy and is a positive mediator of ER stress-induced and gamma-interferon induced programmed cell death. Catalytic activity is increased by ER stress. Inhibited by autophosphorylation of S308. DAPK -/- cells are protected from ER stress-induced cell death, and both apoptosis and autophagy are decreased. Colocalizes with the actin filament system. It is a tumor suppressor candidate, activating p53-dependent apoptosis. Expression is reduced in some cancers, and the promoter is frequently hypermethylated in invasive cancers. Increased expression and mislocalization is seen in epilepsy, where it may regulate neuronal death. A structurally unique serine-threonine kinase that carries eight ankyrin repeats and two putative P-loop consensus sites. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Autophagy; CAMK group; DAPK family; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 9q21.33
Cellular Component: actin cytoskeleton; cytoplasm; plasma membrane
Molecular Function: ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; identical protein binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; syntaxin-1 binding
Biological Process: apoptosis; negative regulation of translation; positive regulation of autophagy; positive regulation of caspase activity; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of autophagy
Reference #:  P53355 (UniProtKB)
Alt. Names/Synonyms: DAP kinase 1; DAPK; DAPK1; Death-associated protein kinase 1; DKFZp781I035
Gene Symbols: DAPK1
Molecular weight: 160,046 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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