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TCEB3 SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). Heterotrimer of an A (A1, A2 or A3), B and C subunit. The C subunit mediates the binding of the elongin BC complex to subunit A. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: extracellular space; nucleoplasm
Molecular Function: protein binding
Biological Process: regulation of transcription from RNA polymerase II promoter; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Reference #:  Q14241 (UniProtKB)
Alt. Names/Synonyms: EloA; ELOA1; Elongin 110 kDa subunit; elongin A; Elongin-A; FLJ38760; FLJ42849; RNA polymerase II transcription factor SIII subunit A1; SIII; SIII p110; TCEB3; TCEB3A; transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A); transcription elongation factor B alpha subunit; Transcription elongation factor B polypeptide 3
Gene Symbols: TCEB3
Molecular weight: 89,909 Da
Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states
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