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FKBP5 Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP. Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the complex when NR3C1 binds glucocorticoid. By androgen. Widely expressed, enriched in testis compared to other tissues. Inhibited by FK506 but not cyclosporin. Note: This description may include information from UniProtKB.
Protein type: Chaperone; EC; Isomerase
Chromosomal Location of Human Ortholog: 6p21.31
Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm
Molecular Function: FK506 binding; heat shock protein binding; peptidyl-prolyl cis-trans isomerase activity; protein binding
Biological Process: protein folding
Disease: Major Depressive Disorder
Reference #:  Q13451 (UniProtKB)
Alt. Names/Synonyms: 51 kDa FK506-binding protein; 51 kDa FK506-binding protein 5; 51 kDa FKBP; 54 kDa progesterone receptor-associated immunophilin; AIG6; Androgen-regulated protein 6; FF1 antigen; FK506 binding protein 5; FK506-binding protein 5; FKBP-5; FKBP-51; FKBP5; FKBP51; FKBP54; HSP90-binding immunophilin; MGC111006; p54; Peptidyl-prolyl cis-trans isomerase FKBP5; peptidylprolyl cis-trans isomerase; PPIase FKBP5; Ptg-10; T-cell FK506-binding protein
Gene Symbols: FKBP5
Molecular weight: 51,212 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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