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PPIG an ubiquitous peptidyl-prolyl cis/trans isomerase. Distributed in nuclear speckles, which are rich in splicing factors. Colocalizes with the splicing factor SFRS2. A component of splicing factor complexes that bind the phosphorylated C-terminal domain (CTD) of RNA polymerase II. Interacts with CLK1 and PNN. Two splice variant isoforms of the human protein have been described. Note: This description may include information from UniProtKB.
Protein type: Cyclophilin; EC; Isomerase
Chromosomal Location of Human Ortholog: 2q31.1
Cellular Component: cytosol; nuclear speck; nucleoplasm; nucleus
Molecular Function: cyclosporin A binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; RNA binding
Biological Process: RNA splicing
Reference #:  Q13427 (UniProtKB)
Alt. Names/Synonyms: CARS-cyclophilin; CARS-Cyp; CASP10; Clk-associating RS-cyclophilin; Cyclophilin G; CYP; MGC133241; Peptidyl-prolyl cis-trans isomerase G; Peptidyl-prolyl isomerase G; peptidyl-prolyl isomerase G (cyclophilin G); peptidylprolyl isomerase G (cyclophilin G); PPIase G; PPIG; Rotamase G; SR-cyclophilin; SR-cyp; SRcyp
Gene Symbols: PPIG
Molecular weight: 88,617 Da
Basal Isoelectric point: 10.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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