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NUP98 Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). The repeat domain in Nup98 has a direct role in the transport. Nup98 interacts directly with Nup96. Nup96 is part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus. May interact with RAE1. Interacts with vesicular stomatitis virus protein M. Belongs to the nucleoporin GLFG family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Nucleoporin
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component: cytosol; intracellular membrane-bound organelle; intracellular ribonucleoprotein complex; kinetochore; nuclear body; nuclear envelope; nuclear inclusion body; nuclear membrane; nuclear pore; nucleoplasm
Molecular Function: mRNA binding; nuclear localization sequence binding; nucleocytoplasmic transporter activity; protein binding; RNA binding; serine-type peptidase activity; structural constituent of nuclear pore; transporter activity
Biological Process: DNA replication; mitotic nuclear envelope disassembly; mRNA export from nucleus; nuclear pore complex assembly; nuclear pore organization and biogenesis; nucleocytoplasmic transport; positive regulation of mRNA splicing, via spliceosome; positive regulation of transcription from RNA polymerase II promoter; protein import into nucleus; protein sumoylation; proteolysis; regulation of glycolysis; RNA export from nucleus; sister chromatid cohesion; tRNA export from nucleus; viral process; viral transcription
Reference #:  P52948 (UniProtKB)
Alt. Names/Synonyms: 96 kDa nucleoporin; 98 kDa nucleoporin; ADAR2; ADIR2; GLFG-repeat containing nucleoporin; Nuclear pore complex protein Nup96; Nuclear pore complex protein Nup98; Nuclear pore complex protein Nup98-Nup96; nucleoporin 98kDa; Nucleoporin Nup96; Nucleoporin Nup98; NUP196; NUP96; NUP98; Nup98-Nup96
Gene Symbols: NUP98
Molecular weight: 197,579 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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