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MECP2 Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Interacts with FNBP3. Interacts with CDKL5. Present in all adult somatic tissues tested. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: centrosome; cytosol; extracellular space; gamma-tubulin complex; heterochromatin; nucleus
Molecular Function: DNA binding; double-stranded methylated DNA binding; methyl-CpG binding; protein binding; protein domain specific binding; protein N-terminus binding; RNA binding; transcription corepressor activity
Biological Process: locomotory behavior; mitotic spindle organization and biogenesis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of cell proliferation; response to radiation
Disease: Autism, Susceptibility To, X-linked 3; Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations; Lubs X-linked Mental Retardation Syndrome; Mental Retardation, X-linked, Syndromic 13; Rett Syndrome
Reference #:  P51608 (UniProtKB)
Alt. Names/Synonyms: AUTSX3; DKFZp686A24160; MeCp-2 protein; MECP2; methyl CpG binding protein 2 (Rett syndrome); Methyl-CpG-binding protein 2; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT
Gene Symbols: MECP2
Molecular weight: 52,441 Da
Basal Isoelectric point: 9.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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