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SMARCA2 an enzyme with ATP-dependent DNA helicase activity. A transcriptional coactivator that cooperates with nuclear hormone receptors to potentiate transcriptional activation. Binds TOPBP1. Belongs to the SNF2/RAD54 helicase family. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 9p24.3
Cellular Component: intermediate filament cytoskeleton; intracellular membrane-bound organelle; nuclear chromatin; nucleoplasm; nucleus; SWI/SNF complex
Molecular Function: DNA-dependent ATPase activity; protein binding; transcription coactivator activity
Biological Process: chromatin remodeling; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent
Disease: Nicolaides-baraitser Syndrome
Reference #:  P51531 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase SMARCA2; BAF190; BAF190B; BRG1-associated factor 190B; BRM; FLJ36757; hBRM; hSNF2a; MGC74511; Probable global transcription activator SNF2L2; Protein brahma homolog; SMARCA2; SMCA2; SNF2; SNF2-alpha; SNF2-like 2; SNF2/SWI2-like protein 2; SNF2A; SNF2L2; SNF2LA; Sth1p; sucrose nonfermenting 2-like protein 2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2; SWI2
Gene Symbols: SMARCA2
Molecular weight: 181,279 Da
Basal Isoelectric point: 6.76  Predict pI for various phosphorylation states
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