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FASN a multifunctional enzyme. Catalyzes the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC; EC; EC; EC; EC; EC; EC; EC; Hydrolase; Lipid Metabolism - fatty acid biosynthesis; Lyase; Oxidoreductase
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: cytosol; Golgi apparatus; membrane; plasma membrane
Molecular Function: cadherin binding; fatty-acid synthase activity; protein binding; RNA binding
Biological Process: acyl-CoA biosynthetic process; fatty acid metabolic process; osteoblast differentiation; pantothenate metabolic process; positive regulation of cellular metabolic process; regulation of cholesterol biosynthetic process
Reference #:  P49327 (UniProtKB)
Alt. Names/Synonyms: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-oxoacyl-[acyl-carrier-protein] synthase; [Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; Enoyl-[acyl-carrier-protein] reductase; FAS; FASN; Fatty acid synthase; MGC14367; MGC15706; OA-519; Oleoyl-[acyl-carrier-protein] hydrolase; SDR27X1; short chain dehydrogenase/reductase family 27X, member 1
Gene Symbols: FASN
Molecular weight: 273,427 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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