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JARID1C Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Part of two distinct complexes, one containing E2F6, and the other containing REST. Expressed in all tissues examined. Highest levels found in brain and skeletal muscle. Belongs to the JARID1 histone demethylase family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase
Chromosomal Location of Human Ortholog: Xp11.22
Cellular Component: cytosol; nucleoplasm; nucleus
Molecular Function: histone demethylase activity; histone demethylase activity (H3-K4 specific); zinc ion binding
Biological Process: negative regulation of transcription, DNA-dependent
Disease: Mental Retardation, X-linked, Syndromic, Claes-jensen Type
Reference #:  P41229 (UniProtKB)
Alt. Names/Synonyms: DXS1272E; Histone demethylase JARID1C; JARID1C; JmjC domain-containing protein SMCX; Jumonji, AT rich interactive domain 1C (RBP2-like); Jumonji/ARID domain-containing protein 1C; KDM5C; lysine (K)-specific demethylase 5C; Lysine-specific demethylase 5C; MRXJ; MRXSJ; Protein SmcX; Protein Xe169; selected cDNA on X; SMCX; Smcx homolog, X chromosome; Smcy homolog, X-linked; XE169
Gene Symbols: KDM5C
Molecular weight: 175,720 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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