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CDK2 a protein kinase of the CDK family. An important component of the cell cycle machinery. Activity of CDK2 is maximal during S phase and G2. Cdk2/cyclin E kinase activity is important for the G1 to S transition and phosphorylates the Rb protein. In S-phase, active cdk2/cyclin A complexes predominate and phosphorylate E2F, and the active cdk2 complex persists in the nucleus through G2. Part of the Rb pathway disregulated in most tumors. Target of several candidate cancer drugs. However, inhibition does not always prevent cancer cell growth, possibly due to CDK redundancy. Inhibitors: BMS-265246, BMS-265246-01, R-roscovitine (CYC200, CYC202), SU9516, R547, L868276 Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CDK1 subfamily; CDK1 subfamily; CMGC group; Cell cycle regulation; EC; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 12q13.2
Cellular Component: Cajal body; centrosome; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; endosome; nucleoplasm; nucleus
Molecular Function: cyclin binding; cyclin-dependent protein kinase activity; histone kinase activity; kinase activity; protein binding; protein domain specific binding; protein serine/threonine kinase activity
Biological Process: centriole replication; centrosome duplication; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA replication; G1 DNA damage checkpoint; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; histone phosphorylation; meiotic cell cycle; multicellular organismal development; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; peptidyl-serine phosphorylation; positive regulation of cell proliferation; protein amino acid phosphorylation; Ras protein signal transduction; regulation of G2/M transition of mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; response to organic substance
Reference #:  P24941 (UniProtKB)
Alt. Names/Synonyms: cdc2-related protein kinase; CDK2; cell devision kinase 2; Cell division protein kinase 2; cyclin-dependent kinase 2; p33 protein kinase; p33(CDK2)
Gene Symbols: CDK2
Molecular weight: 33,930 Da
Basal Isoelectric point: 8.8  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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