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Restin Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. Interacts with MTOR; phosphorylates and regulates CLIP1. Interacts (via CAP-Gly domains) with tubulin. Interacts with SLAIN2. Interacts (via zinc finger) with DCTN1. Interacts with MAPRE1 and MAPRE3. Detected in dendritic cells. Highly expressed in the Reed-Sternberg cells of Hodgkin disease. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: centrosome; cytosol; endosome; intermediate filament; kinetochore; microtubule; microtubule cytoskeleton
Molecular Function: microtubule binding; microtubule plus-end binding; protein binding; protein homodimerization activity; tubulin binding; zinc ion binding
Biological Process: microtubule bundle formation; mitotic cell cycle; positive regulation of microtubule polymerization; sister chromatid cohesion
Reference #:  P30622 (UniProtKB)
Alt. Names/Synonyms: CAP-GLY domain containing linker protein 1; CAP-Gly domain-containing linker protein 1; CLIP; CLIP-170; CLIP1; CLIP170; CYLN1; cytoplasmic linker 1; Cytoplasmic linker protein 1; Cytoplasmic linker protein 170 alpha-2; MGC131604; Reed-Steinberg cell-expressed intermediate filament-associated protein; Reed-Sternberg intermediate filament-associated protein; Restin; restin (Reed-Steinberg cell-expressed intermediate filament-associated protein); RSN
Gene Symbols: CLIP1
Molecular weight: 162,246 Da
Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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