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JARID1A Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Interacts with SUZ12; the interaction is direct. Interacts with the viral protein-binding domain of RB1. Interacts with ESR1, MYC, MYCN and LMO2. Belongs to the JARID1 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.11.-; Nuclear receptor co-regulator; Nucleolus; Oxidoreductase; Transcription factor
Chromosomal Location of Human Ortholog: 12p13.33
Cellular Component: cyclin-dependent protein kinase activating kinase holoenzyme complex; nucleoplasm; nucleus
Molecular Function: DNA binding; histone demethylase activity; histone demethylase activity (H3-K9 specific); protein binding; transcription coactivator activity; transcription factor activity
Biological Process: circadian regulation of gene expression; histone H3-K9 demethylation; positive regulation of transcription, DNA-dependent; regulation of transcription factor activity; transcription from RNA polymerase II promoter
Reference #:  P29375 (UniProtKB)
Alt. Names/Synonyms: Histone demethylase JARID1A; JARID1A; Jumonji, AT rich interactive domain 1A (RBBP2-like); Jumonji, AT rich interactive domain 1A (RBP2-like); Jumonji/ARID domain-containing protein 1A; KDM5A; lysine (K)-specific demethylase 5A; Lysine-specific demethylase 5A; RBBP-2; RBBP2; RBP2; retinoblastoma binding protein 2; Retinoblastoma-binding protein 2
Gene Symbols: KDM5A
Molecular weight: 192,095 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation  |  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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