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YY1 a polycomb-group (Pc-G) protein essential for early mammalian development and the regulation of X-inactivation and certain imprinted genes. Required for the transactivation of TSIX by CTCF. The complex of CTCF-YY1-TSIX is a critical regulator of the X chromosome binary switch. Can function as an activator or a repressor depending on the presence of other proteins. For example it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor
Chromosomal Location of Human Ortholog: 14q32.2
Cellular Component: nucleoplasm; nucleus
Molecular Function: DNA binding; four-way junction DNA binding; protein binding; RNA binding; SMAD binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity; zinc ion binding
Biological Process: double-strand break repair via homologous recombination; negative regulation of interferon-beta production; negative regulation of transcription from RNA polymerase II promoter; protein deubiquitination; regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; response to UV-C
Disease: Gabriele-de Vries Syndrome
Reference #:  P25490 (UniProtKB)
Alt. Names/Synonyms: DELTA; Delta transcription factor; INO80 complex subunit S; INO80S; NF-E1; Transcriptional repressor protein YY1; TYY1; UCRBP; Yin and yang 1; Yin and Yang 1 protein; yin yang 1; YIN-YANG-1; YY-1; YY1; YY1 transcription factor
Gene Symbols: YY1
Molecular weight: 44,713 Da
Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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