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RPS3 a component of the 40S ribosomal subunit of eukaryotes. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Overexpressed in colorectal cancer. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; RNA-binding; Ribosomal; Translation
Chromosomal Location of Human Ortholog: 11q13.4
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; extracellular matrix; focal adhesion; membrane; mitochondrial inner membrane; mitochondrial matrix; nucleolus; nucleoplasm; nucleus; plasma membrane; polysome; ribonucleoprotein complex; ribosome
Molecular Function: damaged DNA binding; DNA binding; DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; endodeoxyribonuclease activity; enzyme binding; Hsp70 protein binding; Hsp90 protein binding; kinase binding; microtubule binding; mRNA binding; oxidized purine DNA binding; oxidized pyrimidine DNA binding; protein binding; protein complex binding; protein kinase A binding; protein kinase binding; RNA binding; structural constituent of ribosome; SUMO binding; transcription factor binding; tubulin binding
Biological Process: activation of NF-kappaB transcription factor; chromosome segregation; DNA damage response, detection of DNA damage; mRNA catabolic process, nonsense-mediated decay; negative regulation of DNA repair; negative regulation of protein ubiquitination; negative regulation of translation; positive regulation of activated T cell proliferation; positive regulation of DNA repair; positive regulation of endodeoxyribonuclease activity; positive regulation of interleukin-2 production; positive regulation of JNK activity; positive regulation of microtubule polymerization; positive regulation of protein complex assembly; positive regulation of T cell receptor signaling pathway; regulation of apoptosis; response to DNA damage stimulus; response to oxidative stress; rRNA processing; spindle assembly; SRP-dependent cotranslational protein targeting to membrane; translation; translational initiation; viral transcription
Reference #:  P23396 (UniProtKB)
Alt. Names/Synonyms: 40S ribosomal protein S3; FLJ26283; FLJ27450; IMR-90 ribosomal protein S3; MGC87870; ribosomal protein S3; RPS3; RS3
Gene Symbols: RPS3
Molecular weight: 26,688 Da
Basal Isoelectric point: 9.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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