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Oct1 a ubiquitous transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. Phosphorylation apparently inhibits its interaction with DNA. Four splice variant isoforms have been described. Isoform 2 is lymphocyte specific. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 1q24.2
Cellular Component: endoplasmic reticulum; intracellular membrane-bound organelle; nucleoplasm; nucleus
Molecular Function: DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; snRNA transcription from RNA polymerase II promoter
Reference #:  P14859 (UniProtKB)
Alt. Names/Synonyms: NF-A1; Oct-1; OCT1; Octamer-binding protein 1; Octamer-binding transcription factor 1; Octamer-binding transcription factor-1; OTF-1; OTF1; PO2F1; POU class 2 homeobox 1; POU domain, class 2, transcription factor 1; POU2F1
Gene Symbols: POU2F1
Molecular weight: 76,472 Da
Basal Isoelectric point: 6.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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