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Ferritin-H Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited. Belongs to the ferritin family. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC; Oxidoreductase
Chromosomal Location of Human Ortholog: 11q12.3
Cellular Component: cytosol; extracellular region; ferritin complex; nucleus
Molecular Function: iron ion binding; protein binding
Biological Process: cellular iron ion homeostasis; immune response; intracellular sequestering of iron ion; negative regulation of cell proliferation; negative regulation of fibroblast proliferation; neutrophil degranulation
Disease: Hemochromatosis, Type 5
Reference #:  P02794 (UniProtKB)
Alt. Names/Synonyms: apoferritin; Cell proliferation-inducing gene 15 protein; Ferritin H subunit; Ferritin heavy chain; ferritin, heavy polypeptide 1; FHC; FRIH; FTH; FTH1; FTHL6; MGC104426; PIG15; placenta immunoregulatory factor; PLIF; proliferation-inducing protein 15
Gene Symbols: FTH1
Molecular weight: 21,226 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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