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CDK7 a protein kinase of the CDK family. Forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). Activates the cyclin-associated kinases CDK1, -2, -4 and -6. An essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. Serves as a direct link between the regulation of transcription and the cell cycle. Phosphorylates and activates RNA polymerase II, allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CDK7 subfamily; CDK7 subfamily; CMGC group; Cell cycle regulation; EC; EC; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 5q13.2
Cellular Component: cyclin-dependent protein kinase activating kinase holoenzyme complex; cytoplasm; holo TFIIH complex; nucleoplasm; nucleus; perinuclear region of cytoplasm; TFIIK complex
Molecular Function: androgen receptor binding; ATP binding; cyclin-dependent protein kinase activity; DNA-dependent ATPase activity; kinase activity; protein binding; protein C-terminus binding; protein kinase activity; protein serine/threonine kinase activity; RNA polymerase II carboxy-terminal domain kinase activity; transcription coactivator activity
Biological Process: 7-methylguanosine mRNA capping; androgen receptor signaling pathway; cell cycle arrest; cell division; cell proliferation; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; nucleotide-excision repair, preincision complex assembly; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein amino acid phosphorylation; protein stabilization; regulation of cyclin-dependent protein kinase activity; RNA elongation from RNA polymerase I promoter; snRNA transcription from RNA polymerase II promoter; termination of RNA polymerase I transcription; transcription elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase I promoter; transcription initiation from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair
Reference #:  P50613 (UniProtKB)
Alt. Names/Synonyms: 39 kDa protein kinase; CAK; CAK1; CDK-activating kinase; CDK7; CDKN7; Cell division protein kinase 7; cyclin-dependent kinase 7; cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); homolog of Xenopus MO15 Cdk-activating kinase; kinase subunit of CAK; MO15; p39 Mo15; p39MO15; serine/threonine kinase stk1; serine/threonine protein kinase 1; serine/threonine protein kinase MO15; STK1; TFIIH basal transcription factor complex kinase subunit
Gene Symbols: CDK7
Molecular weight: 39,038 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint  |  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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