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N-CoR1 is a protein that regulates the activity of some transcription factors, including nuclear receptors, by promoting histone deacetylation and chromatin condensation, thereby altering the accessibility of various genes to the transcriptional machinery. Is known to play a role genetic programming including that for myogenesis. Is a component of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid and the retinoic acid receptors in the absence of ligand. Interacts with the catalytic domain of HDAC9. Increased expression correlates with the loss of vitamin D responsiveness in aggressive androgen-independent prostate cancer cells. Its gene tends to be overexpressed in multiple-myeloma cell lines. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 17p12-p11.2
Cellular Component: cytosol; histone deacetylase complex; membrane; nuclear chromatin; nucleoplasm; nucleus; Sin3 complex; spindle microtubule; transcriptional repressor complex
Molecular Function: histone deacetylase binding; ligand-dependent nuclear receptor binding; nuclear hormone receptor binding; protein binding; thyroid hormone receptor binding; transcription corepressor activity
Biological Process: circadian rhythm; negative regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; regulation of lipid metabolic process; spindle assembly; transcription from RNA polymerase II promoter
Reference #:  O75376 (UniProtKB)
Alt. Names/Synonyms: hCIT529I10; hN-CoR; KIAA1047; MGC104216; N-CoR; N-CoR1; NCOR1; nuclear receptor co-repressor 1; Nuclear receptor corepressor 1; thyroid hormone- and retinoic acid receptor-associated corepressor 1; TRAC1
Gene Symbols: NCOR1
Molecular weight: 270,210 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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