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KIF1B a member of the kinesin motor protein family. Motor for anterograde transport of mitochondria. May play a role in synaptic vesicle transport. Has a microtubule plus end-directed motility. Aberrant expression seen in neuroblastoma. Mutated in Charcot-Marie-Tooth disease. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motor
Chromosomal Location of Human Ortholog: 1p36.22
Cellular Component: cytoplasmic vesicle; cytoplasmic vesicle membrane; kinesin complex; microtubule associated complex; neuron projection
Molecular Function: ATPase activity; kinesin binding; microtubule motor activity; protein binding
Biological Process: anterograde axon cargo transport; cytoskeleton-dependent intracellular transport; microtubule-based movement; nerve-nerve synaptic transmission; neuromuscular synaptic transmission
Disease: Charcot-marie-tooth Disease, Axonal, Type 2a1; Neuroblastoma, Susceptibility To; Pheochromocytoma
Reference #:  O60333 (UniProtKB)
Alt. Names/Synonyms: CMT2; CMT2A; CMT2A1; FLJ23699; HMSNII; KIAA0591; KIAA1448; KIF1B; kinesin family member 1B; kinesin superfamily protein KIF1B; Kinesin-like protein KIF1B; Klp; MGC134844; NBLST1
Gene Symbols: KIF1B
Molecular weight: 204,476 Da
Basal Isoelectric point: 5.42  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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