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ANKRD3 a TKL protein kinase of the RIPK family. Activates NFkappaB when overexpressed in cell lines and is required for keratinocyte differentiation in vivo. Appears to activate NFkappaB in both a kinase-dependent as well as a kinase-independent manner. Contains 10 ANK repeats. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RIPK family; TKL group
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: cytoplasm
Molecular Function: protein binding
Biological Process: activation of NF-kappaB transcription factor; morphogenesis of an epithelium
Disease: Popliteal Pterygium Syndrome, Lethal Type
Reference #:  P57078 (UniProtKB)
Alt. Names/Synonyms: ANKK2; ANKRD3; ankyrin repeat domain 3; Ankyrin repeat domain-containing protein 3; DIK; MGC129992; MGC129993; PKC-delta-interacting protein kinase; PKK; receptor-interacting serine-threonine kinase 4; Receptor-interacting serine/threonine-protein kinase 4; RIP4; RIPK4; serine/threonine-protein kinase ANKRD3
Gene Symbols: RIPK4
Molecular weight: 91,611 Da
Basal Isoelectric point: 6.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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