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Protein Page:

PPPM1A a Ser/Thr protein phosphatase of the PP2C family. Inhibits the activation of p38 and JNK kinase cascades induced by environmental stresses. Can also dephosphorylate cyclin-dependent kinases and may play a role in cell cycle control. Overexpression of this phosphatase activates the expression of p53, leading to G2/M cell cycle arrest and apoptosis. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 14q23.1
Cellular Component: cytosol; membrane; nucleoplasm; nucleus; plasma membrane
Molecular Function: calmodulin-dependent protein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; signal transducer activity
Biological Process: cell cycle arrest; dephosphorylation; N-terminal protein myristoylation; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of NF-kappaB import into nucleus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription, DNA-dependent; positive regulation of Wnt receptor signaling pathway; protein amino acid dephosphorylation; Wnt receptor signaling pathway
Reference #:  P35813 (UniProtKB)
Alt. Names/Synonyms: FLJ42306; MGC9201; phosphatase 2C alpha; PP2C-alpha; PP2CA; PP2Calpha; PPM1A; PPPM1A; Protein phosphatase 1A; protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform; protein phosphatase 2C alpha isoform; Protein phosphatase 2C isoform alpha; Protein phosphatase IA; protein phosphatase, Mg2+/Mn2+ dependent, 1A
Gene Symbols: PPM1A
Molecular weight: 42,448 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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