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Akt1 an oncogenic AGC kinase that plays a critical role in regulating cell survival and metabolism in many different signaling pathways. Dual phosphorylation is required for its activation. T308 is phosphorylated by PDK1 in the PI3 kinase pathway, and S473 is phosphorylated by mTOR in the mTORC2 pathway. The 'Lys-63'-linked ubiquitination of AKT1 by TRAF6 is important for its translocation to the plasma membrane, phosphorylation, and activation. When Akt is fully phosphorylated it translocates into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its proteosomal degradation. Hyperactive or overexpressed in a number of cancers including breast, prostate, lung, pancreatic, liver, ovarian and colorectal. Over 160 protein substrates are known including many that regulate transcription, metabolism, apoptosis, cell cycle, and growth. Note: This description may include information from UniProtKB.
Protein type: AGC group; AKT family; EC; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 14q32.33
Cellular Component: cytoplasm; cytosol; intercellular junction; microtubule cytoskeleton; mitochondrion; nucleoplasm; nucleus; plasma membrane; postsynapse; protein complex; spindle; vesicle
Molecular Function: 14-3-3 protein binding; ATP binding; enzyme binding; GTPase activating protein binding; identical protein binding; kinase activity; nitric-oxide synthase regulator activity; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding; protein homodimerization activity; protein kinase activity; protein kinase C binding; protein phosphatase 2A binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity
Biological Process: activated T cell apoptosis; activation of protein kinase B activity; aging; anoikis; apoptotic mitochondrial changes; cell differentiation; cell projection organization; cell proliferation; cellular protein modification process; cellular response to cadmium ion; cellular response to DNA damage stimulus; cellular response to epidermal growth factor stimulus; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to organic cyclic compound; cellular response to prostaglandin E stimulus; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; endocrine pancreas development; epidermal growth factor receptor signaling pathway; establishment of protein localization to mitochondrion; G-protein coupled receptor signaling pathway; germ cell development; glucose homeostasis; glucose metabolic process; glucose transport; glycogen biosynthetic process; hyaluronan metabolic process; I-kappaB kinase/NF-kappaB signaling; inflammatory response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; maintenance of protein location in mitochondrion; maternal placenta development; negative regulation of apoptosis; negative regulation of autophagy; negative regulation of cell size; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of endopeptidase activity; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of fatty acid beta-oxidation; negative regulation of gene expression; negative regulation of JNK cascade; negative regulation of macroautophagy; negative regulation of neuron death; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of plasma membrane long-chain fatty acid transport; negative regulation of protein kinase activity; negative regulation of protein kinase B signaling cascade; negative regulation of proteolysis; negative regulation of release of cytochrome c from mitochondria; NIK/NF-kappaB signaling; nitric oxide biosynthetic process; osteoblast differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peripheral nervous system myelin maintenance; phosphoinositide 3-kinase cascade; phosphorylation; platelet activation; positive regulation of apoptosis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cellular protein metabolic process; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of endodeoxyribonuclease activity; positive regulation of endothelial cell proliferation; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of fat cell differentiation; positive regulation of fibroblast migration; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of lipid biosynthetic process; positive regulation of mitochondrial membrane potential; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of organ growth; positive regulation of peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein localization to nucleus; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of sodium ion transport; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; positive regulation of vasoconstriction; protein amino acid phosphorylation; protein autophosphorylation; protein catabolic process; protein import into nucleus, translocation; protein kinase B signaling; protein ubiquitination; regulation of apoptosis; regulation of cell cycle checkpoint; regulation of cell migration; regulation of glycogen biosynthetic process; regulation of mRNA stability; regulation of myelination; regulation of neuron projection development; regulation of nitric-oxide synthase activity; regulation of translation; response to food; response to heat; response to insulin-like growth factor stimulus; response to oxidative stress; signal transduction; spinal cord development; striated muscle cell differentiation; T cell costimulation; TOR signaling; translation
Disease: Breast Cancer; Colorectal Cancer; Cowden Syndrome 6; Ovarian Cancer; Proteus Syndrome; Schizophrenia
Reference #:  P31749 (UniProtKB)
Alt. Names/Synonyms: AKT; AKT1; AKT1 kinase; MGC99656; PKB; PKB-ALPHA; PRKBA; Protein kinase B; Proto-oncogene c-Akt; RAC; rac protein kinase alpha; RAC-ALPHA; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; v-akt murine thymoma viral oncogene homolog 1
Gene Symbols: AKT1
Molecular weight: 55,686 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Alzheimer's Disease  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  G1/S Checkpoint  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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