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Tyk2 a non-receptor tyrosine-protein kinase of the JakA family. Activated in signaling from the IL-2, gp130 and IFN families of receptors. Phosphorylates the interferon-alpha/beta receptor alpha chain. Note: This description may include information from UniProtKB.
Protein type: EC; JakA family; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; nucleus
Molecular Function: growth hormone receptor binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity
Biological Process: cell differentiation; cell migration; innate immune response; protein amino acid phosphorylation; regulation of cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Immunodeficiency 35
Reference #:  P29597 (UniProtKB)
Alt. Names/Synonyms: JTK1; Non-receptor tyrosine-protein kinase TYK2; TYK2; tyrosine kinase 2
Gene Symbols: TYK2
Molecular weight: 133,650 Da
Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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