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ARHGAP26 GTPase-activating protein for RHOA and CDC42. Interacts with NYAP1, NYAP2 and MYO16. Binds to the C-terminus of PTK2/FAK1. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 5q31.3
Cellular Component: cytosol
Molecular Function: GTPase activator activity; phospholipid binding; protein binding
Biological Process: regulation of small GTPase mediated signal transduction
Disease: Juvenile Myelomonocytic Leukemia
Reference #:  Q9UNA1 (UniProtKB)
Alt. Names/Synonyms: ARHGAP26; FLJ42530; GRAF; GTPase regulator associated with focal adhesion kinase; GTPase regulator associated with focal adhesion kinase pp125(FAK); KIAA0621; Oligophrenin-1-like protein; OPHN1L; OPHN1L1; RHG26; Rho GTPase activating protein 26; Rho GTPase-activating protein 26; Rho-type GTPase-activating protein 26
Gene Symbols: ARHGAP26
Molecular weight: 92,235 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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