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ACC1 a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC; EC; Ligase; Lipid Metabolism - fatty acid biosynthesis
Chromosomal Location of Human Ortholog: 11|11 C
Cellular Component: actin cytoskeleton; cytosol; fibrillar center; mitochondrion
Molecular Function: acetyl-CoA carboxylase activity; ATP binding; biotin binding; kinase binding; protein binding
Biological Process: acetyl-CoA metabolic process; fatty acid biosynthetic process; lipid homeostasis; lipid metabolic process; multicellular organismal protein metabolic process; protein homotetramerization; response to organic cyclic substance; tissue homeostasis
Reference #:  Q5SWU9 (UniProtKB)
Alt. Names/Synonyms: A530025K05Rik; Acac; Acaca; ACC-alpha; Acc1; Acetyl-CoA carboxylase 1; Acetyl-CoA carboxylase 265; acetyl-Coenzyme A carboxylase alpha; Biotin carboxylase; Gm738; OTTMUSP00000000931
Gene Symbols: Acaca
Molecular weight: 265,257 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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