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REL a proto-oncogenic transcription factor of the nuclear factor-kappaB (NFkB) group. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. May play a role in differentiation and lymphopoiesis. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 11 A3.2|11 14.36 cM
Cellular Component: cytoplasm; cytosol; nucleus; transcription factor complex
Molecular Function: chromatin binding; protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: cytokine production; I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; negative regulation of interferon-beta production; negative regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-12 biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; response to cytokine stimulus
Reference #:  P15307 (UniProtKB)
Alt. Names/Synonyms: c-Rel; C-Rel proto-oncogene protein; OTTMUSP00000005467; Proto-oncogene c-Rel; Rel; reticuloendotheliosis oncogene
Gene Symbols: Rel
Molecular weight: 64,960 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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