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Protein Page:

4E-BP1 binds to eIF4E, preventing its assembly into the EIF4F complex and inhibiting cap-dependent translation. Phosphorylation of 4E-BP1 disrupts this binding, activating cap-dependent translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the PI3 kinase pathway. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 8 A2|8 15.95 cM
Cellular Component: cytoplasm; cytosol; nucleus; protein complex
Molecular Function: eukaryotic initiation factor 4E binding; protein binding; protein phosphatase 2A binding; translation initiation factor binding; translation repressor activity
Biological Process: G1/S transition of mitotic cell cycle; insulin receptor signaling pathway; negative regulation of protein complex assembly; negative regulation of translational initiation; positive regulation of mitotic cell cycle; regulation of translational initiation; TOR signaling pathway
Reference #:  Q60876 (UniProtKB)
Alt. Names/Synonyms: 4E-BP1; 4EBP1; AA959816; eIF4E-binding protein 1; Eif4ebp1; eukaryotic translation initiation factor 4E binding protein 1; Eukaryotic translation initiation factor 4E-binding protein 1; PHAS-I; Phosphorylated heat- and acid-stable protein regulated by insulin 1
Gene Symbols: Eif4ebp1
Molecular weight: 12,325 Da
Basal Isoelectric point: 5.01  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Angiogenesis  |  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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