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RCC1 a guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP for GTP. Localised generation of Ran-GTP by RCC1 on chromatin is critical for nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; GEF; GEF, Ras
Chromosomal Location of Human Ortholog: 1p35.3
Cellular Component: condensed nuclear chromosome; cytoplasm; nuclear chromatin; nuclear membrane; nucleoplasm; nucleus; protein complex
Molecular Function: chromatin binding; histone binding; nucleosomal DNA binding; nucleosome binding; protein binding; protein heterodimerization activity; Ran GTPase binding; Ran guanyl-nucleotide exchange factor activity; sulfate binding
Biological Process: chromosome segregation; G1/S transition of mitotic cell cycle; mitotic spindle organization and biogenesis; protein heterotetramerization; regulation of mitosis; spindle assembly; viral reproduction
Reference #:  P18754 (UniProtKB)
Alt. Names/Synonyms: Cell cycle regulatory protein; CHC1; chromosome condensation 1; Chromosome condensation protein 1; guanine nucleotide-releasing protein; RCC1; RCC1-I; Regulator of chromosome condensation; regulator of chromosome condensation 1
Gene Symbols: RCC1
Molecular weight: 44,969 Da
Basal Isoelectric point: 7.18  Predict pI for various phosphorylation states
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