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Protein Page:

ARHGEF6 Acts as a RAC1 guanine nucleotide exchange factor (GEF). Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xq26.3
Cellular Component: cytosol; intracellular; lamellipodium
Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity
Biological Process: lamellipodium biogenesis; positive regulation of apoptosis; regulation of small GTPase mediated signal transduction
Disease: Mental Retardation, X-linked 46
Reference #:  Q15052 (UniProtKB)
Alt. Names/Synonyms: Alpha-Pix; alphaPIX; ARHG6; ARHGEF6; COOL-2; COOL2; KIAA0006; mental retardation, X-linked 46; MRX46; PAK-interacting exchange factor alpha; PAK-interacting exchange factor, alpha; PIXA; Rac/Cdc42 guanine exchange factor (GEF) 6; Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Rac/Cdc42 guanine nucleotide exchange factor 6; Rho guanine nucleotide exchange factor 6
Gene Symbols: ARHGEF6
Molecular weight: 87,499 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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