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Afadin plays a role in adhesion by participating, along with E-cadherin and catenin, in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Essential for the association of nectin and E-cadherin. Contains 1 forkhead-associated (FHA) domain, a phosphopeptide recognition domain; 1 dilute (DIL) domain, a myosin-like domain which may play a functional role in cellular processes or vectorial vesicle transport; 1 PDZ domain, which frequently binds the carboxyl-terminal sequences of proteins or phosphatidylinositol 4,5-bisphosphate in the plasma membrane; and 2 RA domains, which are associated with RasGTP effector activity. Five alternatively spliced isoforms have been described. Isoform 2 does not interact with F-actin. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 6q27
Cellular Component: cell junction; cell-cell adherens junction; cytosol; intercellular junction; nuclear speck; nucleoplasm; plasma membrane
Molecular Function: cadherin binding; protein binding; protein C-terminus binding; Ras GTPase binding
Biological Process: cell-cell signaling; positive regulation of GTPase activity; regulation of protein localization
Reference #:  P55196 (UniProtKB)
Alt. Names/Synonyms: AF-6; AF6; AFAD; Afadin; AFDN; ALL1-fused gene from chromosome 6 protein; FLJ34371; MLLT4; myeloid/lymphoid or mixed-lineage leukemia, translocated to, 4; Protein AF-6; RP3-431P23.3; translocated to, 4
Gene Symbols: MLLT4
Molecular weight: 206,804 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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