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TPM1 a cytoskeletal protein that binds to actin filaments in muscle and nonmuscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Defects in TPM3 are a cause of nemaline myopathy type 1 (NEM1). Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 15q22.2
Cellular Component: actin cytoskeleton; actin filament; cytoskeleton; cytosol; muscle thin filament tropomyosin; sarcomere; stress fiber
Molecular Function: actin binding; actin filament binding; cytoskeletal protein binding; protein binding; structural constituent of cytoskeleton; structural constituent of muscle
Biological Process: actin filament organization; cardiac muscle contraction; cell motility; cytoskeleton organization and biogenesis; muscle contraction; muscle filament sliding; negative regulation of cell migration; positive regulation of ATPase activity; positive regulation of cell adhesion; positive regulation of heart rate by epinephrine; positive regulation of stress fiber formation; regulation of cell shape; regulation of heart contraction; regulation of muscle contraction; ruffle organization and biogenesis; sarcomere organization; ventricular cardiac muscle morphogenesis; wound healing
Disease: Cardiomyopathy, Dilated, 1y; Cardiomyopathy, Familial Hypertrophic, 3
Reference #:  P09493 (UniProtKB)
Alt. Names/Synonyms: alpha tropomyosin; Alpha-tropomyosin; C15orf13; cardiomyopathy, hypertrophic 3; CMD1Y; HTM-alpha; sarcomeric tropomyosin kappa; TMSA; TPM1; tropomyosin 1 (alpha); Tropomyosin alpha-1 chain; Tropomyosin-1
Gene Symbols: TPM1
Molecular weight: 32,709 Da
Basal Isoelectric point: 4.69  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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