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REPS1 a vesicle-associated protein that influences endocytosis through its ability to interact with Rab11FIP2 and RALBP1. An EGFR substrate that interacts with CRK and GRB2. May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. Binding to RALBP1 does not affect its Ral-binding activity. Forms a complex with the SH3 domains of CRK and GRB2. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 6q24.1
Cellular Component: coated pit; cytosol; plasma membrane
Molecular Function: protein binding; SH3 domain binding
Reference #:  Q96D71 (UniProtKB)
Alt. Names/Synonyms: RALBP1; RALBP1 associated Eps domain containing 1; RalBP1-associated Eps domain-containing protein 1; RalBP1-interacting protein 1; REPS1
Gene Symbols: REPS1
Molecular weight: 86,662 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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