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GAD67 Catalyzes the production of GABA. Homodimer. Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. Belongs to the group II decarboxylase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - butanoate; EC; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Other Amino Acids Metabolism - taurine and hypotaurine
Chromosomal Location of Human Ortholog: 2q31.1
Cellular Component: intracellular; plasma membrane
Molecular Function: glutamate decarboxylase activity; protein binding
Biological Process: glutamate catabolic process; glutamate decarboxylation to succinate; neurotransmitter secretion; protein-pyridoxal-5-phosphate linkage; synaptic transmission
Disease: Cerebral Palsy, Spastic Quadriplegic, 1
Reference #:  Q99259 (UniProtKB)
Alt. Names/Synonyms: 67 kDa glutamic acid decarboxylase; DCE1; FLJ45882; GAD; GAD-67; GAD1; GAD67; Glutamate decarboxylase 1; glutamate decarboxylase 1 (brain, 67kDa); Glutamate decarboxylase 67 kDa isoform; SCP
Gene Symbols: GAD1
Molecular weight: 66,897 Da
Basal Isoelectric point: 7.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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