Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

FGF2 Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. Belongs to the heparin-binding growth factors family. 4 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Activator; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3 B|3 18.41 cM
Cellular Component: cytoplasm; extracellular space; nucleus
Molecular Function: chemoattractant activity; cytokine activity; fibroblast growth factor receptor binding; growth factor activity; ligand-dependent nuclear receptor transcription coactivator activity; protein binding
Biological Process: activation of MAPKK activity; adrenocorticotropin hormone secreting cell differentiation; angiogenesis; cardiac muscle cell proliferation; cell migration during sprouting angiogenesis; embryonic development ending in birth or egg hatching; fibroblast growth factor receptor signaling pathway; glial cell differentiation; growth factor dependent regulation of satellite cell proliferation; hyaluronan catabolic process; induction of an organ; inositol phosphate biosynthetic process; lung development; negative regulation of blood vessel endothelial cell migration; negative regulation of cell proliferation; phosphatidylinositol biosynthetic process; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cardiac muscle cell proliferation; positive regulation of cell differentiation; positive regulation of cell fate specification; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of granule cell precursor proliferation; positive regulation of MAP kinase activity; positive regulation of osteoblast differentiation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of cell cycle; regulation of retinal cell programmed cell death; release of sequestered calcium ion into cytosol; response to axon injury; stem cell development; substantia nigra development; thyroid stimulating hormone secreting cell differentiation; ureteric bud branching; wound healing
Reference #:  P15655 (UniProtKB)
Alt. Names/Synonyms: Basic fibroblast growth factor; BFGF; Fgf-2; Fgf2; Fgfb; fibroblast growth factor 2; HBGF-2; Heparin-binding growth factor 2
Gene Symbols: Fgf2
Molecular weight: 17,153 Da
Basal Isoelectric point: 9.58  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene